Abstract
The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cyclic Nucleotide Phosphodiesterases, Type 7 / antagonists & inhibitors*
-
Cyclic Nucleotide Phosphodiesterases, Type 7 / metabolism*
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Humans
-
Models, Molecular
-
Naphthyridines / chemistry*
-
Naphthyridines / pharmacology*
-
Protein Binding
-
Structure-Activity Relationship
Substances
-
Enzyme Inhibitors
-
Naphthyridines
-
Cyclic Nucleotide Phosphodiesterases, Type 7
-
PDE7A protein, human